What is Sildenafil?
Sildenafil is a PDE-5 inhibitor drug which is now primarily used to treat erectile dysfunction(ED) in adult males. Sildenafil is an FDA-approved medicine for the treatment of pulmonary arterial hypertension and erectile dysfunction. As a PDE5 inhibitor, Sildenafil improves blood circulation at specific body parts and improves erectile function and other body areas.
Sildenafil is popularly sold as Generic Viagra; It is the active ingredient in the popular ED pill Viagra manufactured by Pfizer and Revatio as a Cardiovascular drug.
Sildenafil Is also sometimes used off-label to treat conditions like Raynaud's phenomenon.
What are the Medical Uses of Sildenafil Citrate?
Sildenafil citrate is an oral medicine approved to treat a variety of medical conditions, including:
- Erectile Dysfunction (ED) or Impotence
- Pulmonary Arterial Hypertension (PAH)
How Does Sildenafil Work?
Sildenafil citrate is a PDE5 inhibitor that helps improve blood flow to the penis. PDE5 is an enzyme causing the breaking down of cGMP, which relaxes the smooth muscles in blood vessels. When Sildenafil inhibits PDE5, the levels of cGMP increase, allowing the blood vessels in the penis to relax and improve blood flow during sexual stimulation. This enhanced blood flow helps a man achieve and maintain a naturally firm erection.
How to Take Sildenafil?
Sildenafil dosage is available in various strengths, including 20mg, 25mg, 50mg, 100mg tablets, and other forms.
To improve erectile function, Sildenafil takes 30 to 60 minutes before planned sexual activity.
You can take Sildenafil before or after your meal, though taking it on an empty stomach for faster absorption.
Remember, sexual stimulation is necessary for Sildenafil to be effective in helping you achieve and maintain an erection.
How long does Sildenafil Last?
Once taken, Sildenafil typically lasts for 4 to 5 hours, allowing you to maintain an erection and improve sexual performance. The effects of Sildenafil can remain for up to 24 hours on your body.
What if I consume an overdose of Sildenafil?
Using a higher dose of Sildenafil than the prescribed one can be unsafe and might lead to unwanted effects. Overdosing can cause:
- Headache
- Dizziness
- Prolong erection
- Blurred vision
In case you consume an overdose by mistake, seek medical help.
What are the Side Effects of Sildenafil?
Common side effects seen during the use of Sildenafil include:
- Headaches
- Muscle pain
- Tingling sensations
- Flushing
- Sensitivity to light
If you experience any of these side effects and they do not subside, seek medical advice.
What are the drug Interactions for Sildenafil?
Like any other medication, Sildenafil may interact with certain drugs, including:
- Nitrates (used for chest pain or angina)
- Blood pressure and heart medications, such as diuretics, ACE inhibitors, and calcium channel blockers
- Other ED medications, including other PDE5 inhibitors
- Medications for pulmonary hypertension
- Cytochrome P450 drugs, such as clopidogrel, cimetidine, fluvoxamine, and modafinil
- Antifungal and antibiotic drugs
- HIV medications
- Recreational drugs, dietary supplements, and over-the-counter medicines
Always discuss all medications you are currently taking with your doctor to avoid any harmful interactions.
What are the Safety Advice and Precautions Related to Sildenafil?
Allergy alert: If allergic to Sildenafil, do not take this medication.
Avoid nitrates: Do not use nitrate drugs (e.g., for chest pain) with Generic Sildenafil.
One dose per day: Never take more than one dose of Sildenafil equivalent in 24 hours.
Limit alcohol: If you regularly drink alcohol, limit or avoid alcohol consumption while taking Sildenafil, as it can increase side effects.
Medical conditions: Inform your doctor if you have any of the following conditions:
- Heart, liver, or kidney disease
- High or low blood pressure
- Chronic kidney disease
- Priapism
- Seizures
- Pigmentosa Retinitis
- Any other significant health conditions
Food Interactions: Avoid following food items while using Sildenafil.
- Grapefruit
- Alcohol
- Tobacco
- Grapefruit juice
Prescription-only: Generic Viagra is available only with a prescription. It is intended for men aged 18 and older who have erectile dysfunction (ED).
Liver or kidney disease: If you have liver or kidney problems, use Viagra or its generic form with caution.
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