PDE-5 Inhibitors: Perfect Medications Helping Men to Deal With ED

PDE-5 Inhibitors: Perfect Medications Helping Men to Deal With ED
Published : Feb 05, 2024
Last Updated : Feb 07, 2024

Are you searching online for information about treating erectile dysfunction?

If the answer is yes, then you must have heard about one of the famous medications called PDE-5 inhibitors. 

Although several drugs help treat Erectile Dysfunction, medicines are also highly effective. 

Erectile dysfunction is the condition when a man is not able to get and maintain the erection required for sexual intercourse. 

So, are you suffering from erectile dysfunction and want to bring back your sexual life on track?

If the answer to this question is yes, then give it a try on Phosphodiesterase-5 inhibitor drugs once. 

You must know that these medications help improve blood flow to specific tissues. 

As a result, there is a proper flow of blood to the male reproductive organ, and you start experiencing erection. 

Although these drugs were first formulated to treat cardiovascular disease, they are now effective in treating ED. 

Some of the common PDE5 inhibitors available in the market include Viagra, Cialis, Levitra, and Stendra.

However, if you want to know more about these medicines, read this blog.  

What are PDE-5 inhibitors?

PDE-5 inhibitors or phosphodiesterase type 5 inhibitors are the drugs that mainly block the actions of cGMP.

cGMP is an enzyme responsible for regulating blood flow to the male reproductive organ and other body parts. 

By inhibiting PDE5, these medicines make it easy for men to get & maintain an erection. 

You need to know that these drugs work only when you are sexually aroused. 

Remember, these medications are not going to treat other sexual dysfunction problems, such as premature ejaculation. 

How do PDE5 inhibitors work?

PDE-5 inhibitors start working by blocking the effects of the enzyme cGMP-specific phosphodiesterase type-5.

The PDE5 enzyme breaks down a cyclic nucleotide known as cyclic guanosine monophosphate.

cGMP relaxes smooth muscle tissue and regulates blood flow to body parts, including the erectile tissue of the male reproductive organ. 

By blocking the effects of PDE5, the blood flows better in the male reproductive organ during sexual stimulation. 

As a result, it becomes easy to get and maintain an erection. Under sexual arousal, these drugs help improve erectile function in males.

You must know that, like other medicines, the effects of most PDE5 inhibitors are not instant. 

Depending on the medication you take, you need to wait for 15 to 60 minutes to get an erection. 

One of the essential things to consider is that PDE5 inhibitors will not help you to get an erection randomly. 

Instead, the drugs will make it easier for you to develop and maintain an erection at the time of sexual stimulation. 

List of PDE-5 inhibitors

PDE-5 inhibitors are the first and most effective medications that come into the mind for treating ED. At first, these drugs were used to treat conditions like PAH, but later, during clinical trials, they were found to be effective for ED.

Here are some common PDE-5 inhibitors:

Sildenafil (Viagra, Revatio)

Sildenafil is the standard and famous PDE-5 inhibitor that is sold under the brand name Viagra.

This Sex med relieves ED symptoms within an hour and works in 30 to 60 minutes. 

Not only this, but Sildenafil is also a short-acting PDE5 inhibitor. Beyond treating male sexual dysfunction, Sildenafil citrate is also prescribed for pulmonary arterial hypertension.

Tadalafil (Cialis, Adcirca)

Tadalafil is a long-acting PDE5 inhibitor available under the brand name Cialis. 

It is a weekend pill that shows its effects for a long time, i.e., for 36 hours. This ed pill, by improving blood flow to the penis, helps improve erectile function. For patient preference, its dosage is also available in tablet and jelly formation. 

Also, the doctor prescribes doses for pulmonary hypertension and BPH to ease lower urinary tract symptoms. 

You can easily find these drugs in online drugstores at a cost-effective price. 

Avanafil (Stendra)

Available under the brand name Stendra, Avanafil is a new second-generation PDE5 inhibitor. 

This medication works just like Sildenafil as well as Vardenafil, making it easy to get & maintain an erection. 

Vardenafil (Levitra)

Sold under Levitra, Vardenafil is a perfect alternative to Sildenafil. 

This drug is not affected by the food so that you can take it after a meal. 

Always remember that all these ED medications are available only on prescription. 

Make sure you take it under the doctor's supervision to avoid any side effects. 

So, treat ED right from the comfort of your home by ordering PDE type-5 inhibitor medicines from a reputed online pharmacy. 

Can I buy PDE5 Inhibitors over the counter?

The prohibition of over-the-counter sales of PDE5 inhibitors is active. It is not legal to get this class of drugs to treat your medical conditions. It would be best if you had a doctor's prescription.

Side Effects of PDE5 inhibitors:

The use of PDE5 inhibitors, in a few cases, may lead to adverse effects. Generally, they are familiar and mild. Headaches, flushing, stomach discomfort, nasal congestion, muscle and back pain are some of its side effects. In some rare cases, some uncommon side effects like change in eyesight or loss of vision and prolonged or prolonged erection may appear. You must consult a doctor if you suspect any unwanted effects after using these drugs. Usually, these side effects disappear once your body adjusts to the medicine.

Drug Interactions for PDE5 Inhibitors

Phosphodiesterase type 5 (PDE5) inhibitors, Like Sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Levitra), can interact with various medications. Such drug interaction may have risk factors like adverse effects or reduced efficacy. Some notable drug interactions with PDE5 inhibitors include:

Nitrates: Combine use of PDE5 inhibitors with nitrates or nitric oxide can cause severe hypotension. It means you may face a sudden decrease in blood pressure. It happens due to additive vasodilatory effects on the blood vessels. Having severe low blood pressure can pose a significant risk to cardiovascular health.

Alpha-blockers: Medications like terazosin, doxazosin, and tamsulosin treat benign prostatic hyperplasia (BPH) or hypertension(high blood pressure). Combining these drugs can impose hypotensive effects. One may face an increased risk of dizziness and fainting.

Guanylate cyclase stimulators: Drugs like Riociguat are used to treat heart failure, pulmonary hypertension, and other diseases. Using these drugs with PDE5 inhibitors can cause blood pressure to drop suddenly to unsafe levels.

Certain antibiotics and antifungal drugs: Using these drugs with PDE5 Inhibitors may lead to some common side effects. In such cases, you may face low blood pressure, dizziness, and vision problems. Also, specific allergic reactions may appear.

HIV Drugs like Protease inhibitors: Drugs like ritonavir, indinavir, saquinavir, or atazanavir are used to treat HIV. People using these drugs along with PDE5 Inhibitors may face dizziness, vision problems, and allergic reactions. 


PDE5 inhibitors offer effective treatment for erectile dysfunction. ED medications like Viagra, Cialis, Levitra, and Stendra are from this class of drugs. However, it's crucial to understand their mechanisms, potential side effects, and interactions to ensure safe usage. Always consult a healthcare professional before starting any treatment with PDE5 inhibitors.